Up until now your Topaz products worked as single plugins in a host like PS or LR. The new photoFXlab brings them all together in a standalone program. You can access all the presets of the various plugins within photoFXlab and apply them in layers with control of opacity and blend mode. You also have a local adjustment brush to dodge/burn/saturate/mask etc.
The program uses online registration that recognises which plugins you own and can be found HERE.
I will find the progam useful and have paid the discounted intro price of $30 ($80 after a month). Use the code FXLab to get the discount.