I rarely am bothered by noise anymore....unless I'm way up in the stratospheric ISO range.... and even then I just live with it. Now that I'm reminding myself (and you) about it, I may apply it to shadow regions. Also, out of focus areas that are really noisy can be bothersome, but if you denoise the whole image, you lost all the detail of the in focus area. But that is likely just me projecting my own personal tastes.